Rabbit Monoclonal Antibody to APPBP1

The protein encoded by this gene binds to the beta~amyloid precursor protein. Beta~amyloid precursor protein is a cell surface protein with signal~transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin~like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]