Rabbit Monoclonal Antibody to NDUFA1

The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N~terminal hydrophobic domain has the potential to be folded into an alpha~helix spanning the inner mitochondrial membrane with a C~terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two~domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq, Jul 2008]