Rabbit Monoclonal Antibody to SNAP25

Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N~ethylmaleimide~sensitive factor attachment protein receptors) located on the vesicle membrane (v~SNAREs) and the target membrane (t~SNAREs). The assembled v~SNARE/t~SNARE complex consists of a bundle of four helices, one of which is supplied by v~SNARE and the other three by t~SNARE. For t~SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]