Rabbit Monoclonal Antibody to CPT1A

The mitochondrial oxidation of long~chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent~labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent~stable), together with a carnitine~acylcarnitine translocase. CPT I is the key enzyme in the carnitine~dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta~oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]