Rabbit Monoclonal Antibody to DR5

The protein encoded by this gene is a member of the TNF~receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor~related apoptosis inducing ligand (TNFSF10/TRAIL/APO~2L), and transduces an apoptosis signal. Studies with FADD~deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non~coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]