Rabbit Monoclonal Antibody to CD103

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I~domain~containing alpha integrin that undergoes post~translational cleavage in the extracellular domain, yielding disulfide~linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E~cadherin binding integrin known as the human mucosal lymphocyte~1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]