Rabbit Monoclonal Antibody to CD97

This gene encodes a member of the EGF~TM7 subfamily of adhesion G protein~coupled receptors, which mediate cell~cell interactions. These proteins are cleaved by self~catalytic proteolysis into a large extracellular subunit and seven~span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF~like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF~like repeats have been observed for this gene. This gene is found in a cluster with other EGF~TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]