Rabbit Monoclonal Antibody to TAB3

The product of this gene functions in the NF~kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro~inflammatory cytokines TNF or IL~1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF~kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]