Rabbit Monoclonal Antibody to Ku80

The protein encoded by this gene is the 80~kilodalton subunit of the Ku heterodimer protein which is also known as ATP~dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA~binding component of the DNA~dependent protein kinase, and it functions together with the DNA ligase IV~XRCC4 complex in the repair of DNA double~strand break by non~homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs~6, a mutant defective in DNA double~strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]