Rabbit Monoclonal Antibody to TGFBI

This gene encodes an RGD~containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell~collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor~beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]