Rabbit Monoclonal Antibody to CD27

The protein encoded by this gene is a member of the TNF~receptor superfamily. This receptor is required for generation and long~term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B~cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF~kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27~binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]