Rabbit Monoclonal Antibody to Acetyl Coenzyme A Carboxylase

Acetyl~CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin~containing enzyme which catalyzes the carboxylation of acetyl~CoA to malonyl~CoA, the rate~limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC~alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl~CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]