Rabbit Monoclonal Antibody to AMPK alpha 1/2

The protein encoded by this gene is a catalytic subunit of the AMP~activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non~catalytic beta and gamma subunits. AMPK is an important energy~sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl~CoA carboxylase (ACC) and beta~hydroxy beta~methylglutaryl~CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole~body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]