Rabbit Monoclonal Antibody to ATF5

Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'~GTGACGT[AC][AG]~3'), ATF5~specific response element (ARE) (consensus: 5'~C[CT]TCT[CT]CCTT[AT]~3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type~dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down~regulated in order for such cells to exit the cycle and differentiate (By similarity).