Rabbit Monoclonal Antibody to Axin 2

The Axin~related protein, Axin2, presumably plays an important role in the regulation of the stability of beta~catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta~catenin, glycogen synthase kinase 3~beta, and conductin, which leads to the degradation of beta~catenin. Apparently, the deregulation of beta~catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23~q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]