Rabbit Monoclonal Antibody to CaMKII

The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin~dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin~dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long~term potentiation (LTP) and spatial learning. In addition to its calcium~calmodulin (CaM)~dependent activity, this protein can undergo autophosphorylation, resulting in CaM~independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]