Rabbit Monoclonal Antibody to Caspase~11

This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro~inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5~bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non~functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis~related cysteine peptidase", this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9. [provided by RefSeq, Apr 2015]