Rabbit Monoclonal Antibody to FADD

Apoptotic adaptor molecule that recruits caspase~8 or caspase~10 to the activated Fas (CD95) or TNFR~1 receptors. The resulting aggregate called the death~inducing signaling complex (DISC) performs caspase~8 proteolytic activation. Active caspase~8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon~mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity).