Rabbit Monoclonal Antibody to IKB alpha

This gene encodes a member of the NF~kappa~B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF~kappa~B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1~mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T~cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]