Rabbit Monoclonal Antibody to Keap1

This gene encodes a protein containing KELCH~1 like domains, as well as a BTB/POZ domain. Kelch~like ECH~associated protein 1 interacts with NF~E2~related factor 2 in a redox~sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF~E2~related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma~glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]