Rabbit Monoclonal Antibody to MLKL

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase~like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)~induced necroptosis, a programmed cell death process, via interaction with receptor~interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF~induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]