Rabbit Monoclonal Antibody to NF~KB p65

NF~kappa~B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF~kappa~B moves to the nucleus and activates transcription of specific genes. NF~kappa~B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF~kappa~B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]