Rabbit Monoclonal Antibody to P Glycoprotein

The membrane~associated protein encoded by this gene is a member of the superfamily of ATP~binding cassette (ABC) transporters. ABC proteins transport various molecules across extra~ and intra~cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP~dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug~resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood~brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]