Rabbit Monoclonal Antibody to PUMA

This gene encodes a member of the BCL~2 family of proteins. This family member belongs to the BH3~only pro~apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti~apoptotic Bcl~2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro~apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]