Rabbit Monoclonal Antibody to Thymidylate Synthase

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10~methylenetetrahydrofolate (methylene~THF) as a cofactor. This function maintains the dTMP (thymidine~5~prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5~fluorouracil, 5~fluoro~2~prime~deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell~growth progresses from late~log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]