Rabbit Monoclonal Antibody to TRIF

This gene encodes an adaptor protein containing a Toll/interleukin~1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein~protein interactions between the Toll~like receptors (TLRs) and signal~transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll~like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon~beta through activation of nuclear factor kappa~B, during an antiviral immune response. [provided by RefSeq, Jan 2012]