Rabbit Monoclonal Antibody to USP13

Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum~associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34~containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34~containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34~containing complexes regulate p53/TP53 protein levels via USP10 and USP13.