Rabbit Monoclonal Antibody to XIAP

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti~apoptotic function. This protein functions through binding to tumor necrosis factor receptor~associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1~beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell~death proteases, caspase~3 and caspase~7. Mutations in this gene are the cause of X~linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]