Rabbit Monoclonal Antibody to ZAP70

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T~cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T~cell antigen receptor (TCR) stimulation, functions in the initial step of TCR~mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T~cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8~positive T~cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]