Rabbit Monoclonal Antibody to CD86

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen~presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T~lymphocyte~associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T~cell. Binding of this protein with cytotoxic T~lymphocyte~associated protein 4 negatively regulates T~cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]