Rabbit Monoclonal Antibody to Phospho~EIF2S1 (Ser51)

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl~tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36~kD EIF2~alpha subunit (EIF2S1), the 38~kD EIF2~beta subunit (EIF2S2; MIM 603908), and the 52~kD EIF2~gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2~alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]