Rabbit Monoclonal Antibody to Granzyme B

Description
This enzyme is necessary for target cell lysis in cell~mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate~specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase~3, ~7, ~9 and 10 to give rise to active enzymes mediating apoptosis.

Specification
Aliases	Granzyme B; Cathepsin G~like 1; CTSGL1; Lymphocyte protease; Fragmentin~2; Granzyme~2; Human lymphocyte protein; SECT; GZMB; CGL1; CSPB; CTLA1, GRB;
Swissprot	P10144
clone	9C5H8
WB Predicted band size	38kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human
Immunogen	A synthesized peptide derived from human Granzyme B
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Application
IP	1/50
IHC	1/50~1/200
IF/ICC	1/50~1/200