Rabbit Monoclonal Antibody to CDK7

CDK~activating kinase (CAK) is a complex of CDK7 and cyclin H. The complex is involved in cell cycle regulation by phosphorylating an activating residue in the T~loop domain of cdks. Regulation of CAK activity is mediated by T~loop phosphorylation and by association with MAT1, both of which enhance its kinase activity toward the CTD of RNA polymerase II and other substrates such as p53.