Rabbit Monoclonal Antibody to Phospho~Tau (S396)

Tau is a heterogeneous microtubule~associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino~terminal inserts and different numbers of tandem repeats near the carboxy~terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK~3 and CDK5 . Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau.