Rabbit Monoclonal Antibody to ERR alpha

Estrogen~related receptor alpha (ERRα/NR3B1) is an orphan nuclear receptor that controls transcription of genes involved in fatty acid oxidation, glucose metabolism, and mitochondrial biogenesis. The receptor protein contains a non~conserved amino terminal domain (NTD), a central zinc finger DNA binding domain, and a ligand~binding domain. The carboxy~terminal AF2 helix motif of ERRα contains binding sites for nuclear receptor coactivators PGC~1α and PGC~1β. Research studies demonstrate that ERRα transcriptional activity is regulated through phosphorylation and sumoylation within the NTD.