Rabbit Monoclonal Antibody to Raptor

The regulatory associated protein of mTOR (Raptor) was identified as an mTOR binding partner that mediates mTOR signaling to downstream targets. Raptor binds to mTOR substrates, including 4E~BP1 and p70 S6 kinase, through their TOR signaling (TOS) motifs and is required for mTOR~mediated phosphorylation of these substrates. Binding of the FKBP12~rapamycin complex to mTOR inhibits the mTOR~raptor interaction, suggesting a mechanism for rapamycin's specific inhibition of mTOR signaling. This mTOR~raptor interaction and its regulation by nutrients and/or rapamycin is dependent on a protein called GβL.