Rabbit Monoclonal Antibody to Phospho~PKR (T446)

Description
PKR a protein kinase of the PEK family. Upon binding double~stranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis.

Specification
Aliases	E2AK2;E2AK2; EIF2AK1; EIF2AK2; MGC126524; PKR p68 kinase; PKR; PRKR;
Swissprot	P19525
clone	8G1D8
WB Predicted band size	68kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human
Immunogen	A synthesized peptide derived from human Phospho~PKR (T446)
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Application
WB	1/500~1/2000
IP	1/50
IHC	1/50~1/200