Rabbit Polyclonal antibody to CD321

Junctional Adhesion Molecule~A/F11 Receptor (JAM~A/F11R) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. JAM~A regulates multiple cellular processes, including tight junction assembly, epithelial~mesenchymal transition (EMT), leukocyte migration, virus binding, platelet activation, and angiogenesis. Aberrant expression of JAM~A is correlated with poor patient prognosis in several human cancers. In a mouse model of atherosclerosis, an antagonistic peptide that inhibits JAM~A~expressing platelets from interacting with inflamed endothelial cells reduces atherosclerotic plaque formation.