Rabbit Polyclonal antibody to CD305

LAIR~1 is an inhibitory receptor that belongs to the Immunoglobulin superfamily. It has one extracellular Ig~like domain and an intracellular C~terminus with two ITIM (immunoreceptor tyrosine~based inhibitory motif) domains. It is found on peripheral mononuclear cells, including NK, T, and B cells, and is thought to play a negative regulatory role on the cytolytic function of these cells through signaling through collagen ligation. LAIR1 has been noted to be upregulated in renal cell carcinoma, and may play a role in expansion of Th17 cell populations in collagen~rich environments, such as in graft rejection tissue.