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Rabbit Polyclonal antibody to CD161
-
货号：
54471 -
别名：
Killer cell lectin~like receptor subfamily B member 1; C~type lectin domain family 5 member B; HNKR~P1a; NKR~P1A; Natural killer cell surface protein P1A; CD161 -
应用：
WB IF -
反应种属：
Rat,Mouse,Human -
抗体类型：
Primary antibody -
Swissprot：
Q12918 -
规格：
-
数量：
-+ -
说明书：
目录价¥1180
Rabbit Polyclonal antibody to CD161
Description |
|---|
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T~cell proliferation induced by anti~CD3. Acts as a lectin that binds to the terminal carbohydrate Gal~alpha(1,3)Gal epitope as well as to the N~acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell~mediated cytotoxicity as well as interferon~gamma secretion in target cells. |
Specification |
|
|---|---|
| Aliases | Killer cell lectin~like receptor subfamily B member 1; C~type lectin domain family 5 member B; HNKR~P1a; NKR~P1A; Natural killer cell surface protein P1A; CD161 |
| Swissprot | Q12918 |
| clone | 5D2H8 |
| WB Predicted band size | ~43kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles. |
| Species Reactivity | Rat,Mouse,Human |
| Immunogen | Recombinant protein of human CD161. |
| Formulation | 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2. |
Application |
|
|---|---|
| WB | 1/5000~1/10000 |
| IF/ICC | 1/50~1/200 |
Product Image
For Reseach Only
Application Key：WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#54471
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