Rabbit Polyclonal antibody to CD158a

NKAT (NK~associated transcripts) gene products, known as killer immunoglobulin~like receptors or KIRs, downregulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. This family of receptors is characterized by an extracellular region with two to three immunoglobulin~superfamily domains and a cytoplasmic domain with an antigen receptor activation motif (ARAM). KIRs and other inhibitory receptors also possess a common cytoplasmic sequence (I/VxYxxL/V) known as an ITIM (immunoreceptor tyrosine~based inhibitory motif). The human inhibitory natural killer cell immunoglobulin~like receptor 2DL1, also designated KIR2DL1, CL~42, NKAT1, P58.1 or CD158a long form, is a 348 amino acid type I transmembrane protein. KIR2DL1 can bind human leukocyte antigen~C (HLA~C) via both polar and hydrophobic interactions through Met 44 in a binding pocket that coordinates Lys 80 of HLA~C.