Rabbit Polyclonal antibody to CD143

Dipeptidyl carboxypeptidase that removes dipeptides from the C~terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or synaptic plasticity Composed of two similar catalytic domains, each possessing a functional active site, with different selectivity for substrates .Plays a major role in the angiotensin~renin system that regulates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resulting in an increase of the vasoconstrictor activity of angiotensin .Also able to inactivate bradykinin, a potent vasodilator, and therefore enhance the blood pressure response.Acts as a regulator of synaptic transmission by mediating cleavage of neuropeptide hormones, such as substance P,neurotensin or enkephalins .Catalyzes degradation of different enkephalin neuropeptides (Met~enkephalin, Leu~enkephalin, Met~enkephalin~Arg~Phe and possibly Met~enkephalin~Arg~Gly~Leu) . Acts as a regulator of synaptic plasticity in the nucleus accumbens of the brain by mediating cleavage of Met~enkephalin~Arg~Phe, a strong ligand of Mu~type opioid receptor OPRM1, into Met~enkephalin (By similarity).Met~enkephalin~Arg~Phe cleavage by ACE decreases activation of OPRM1, leading to long~term synaptic potentiation of glutamate release (By similarity).Also acts as a regulator of hematopoietic stem cell differentiation by mediating degradation of hemoregulatory peptide N~acetyl~SDKP (AcSDKP).Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1.Involved in amyloid~beta metabolism by catalyzing degradation of Amyloid~beta protein 40 and Amyloid~beta protein 42 peptides, thereby preventing plaque formation.Catalyzes cleavage of cholecystokinin (maturation of Cholecystokinin~8 and Cholecystokinin~5) and Gonadoliberin~1 (both maturation and degradation) hormones.Degradation of hemoregulatory peptide N~acetyl~SDKP (AcSDKP) and amyloid~beta proteins is mediated by the N~terminal catalytic domain, while angiotensin I and cholecystokinin cleavage is mediated by the C~terminal catalytic region.