Rabbit Polyclonal antibody to CD114/CSF3R

Granulocyte colony~stimulating factor receptor (G~CSF~R) is a transmembrane protein comprised of an immunoglobulin~like (Ig~like) domain, a cytokine receptor~homologous (CRH) domain, and three fibronectin type III (FN III) domains. G~CSF~R is expressed on all granulocytic lineages, including progenitor cells, and has been detected on monocytes, T and B lymphocytes, as well as non~hematopoietic tissues including cardiomyocytes and neural stem cells. The primary ligand for G~CSF~R is the cytokine granulocyte colony~stimulating factor (G~CSF). G~CSF~R has no intrinsic tyrosine kinase activity; ligand binding induces conformational changes in the receptor, leading to activation of the Jak/Stat, PI3K/Akt, and MAPK pathways. G~CSF induces differentiation and proliferation of myeloid progenitor cells into neutrophils. Multiple diseases have been associated with mutations of the G~CSF~R gene, CSF3R, including severe congenital neutropenia (SCN), chronic neutrophilic leukemia (CNL), and atypical chronic myeloid leukemia (aCML).