Rabbit Polyclonal antibody to CD6

Cell adhesion molecule that mediates cell~cell contacts and regulates T~cell responses via its interaction with ALCAM/CD166.Contributes to signaling cascades triggered by activation of the TCR/CD3 complex.Functions as costimulatory molecule; promotes T~cell activation and proliferation.Contributes to the formation and maturation of the immunological synapse.Functions as calcium~dependent pattern receptor that binds and aggregates both Gram~positive and Gram~negative bacteria. Binds both lipopolysaccharide (LPS) from Gram~negative bacteria and lipoteichoic acid from Gram~positive bacteria.LPS binding leads to the activation of signaling cascades and down~stream MAP kinases.Mediates activation of the inflammatory response and the secretion of pro~inflammatory cytokines in response to LPS.