Mouse Monoclonal Antibody to COX4 (5B9)

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain.It is a multi~subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane.The complex consists of 13 mitochondrial~ and nuclear~encoded subunits.The mitochondrially~encoded subunits perform the electron transfer and proton pumping activities.The functions of the nuclear~encoded subunits are unknown but they may play a role in the regulation and assembly of the complex.This gene encodes the nuclear~encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme.It is located at the 3´ of the NOC4 (neighbor of COX4) gene in a head~to~head orientation,and shares a promoter with it.