Rabbit polyclonal antibody to BMAL2

BMAL2, also known as ARNTL2 (aryl hydrocarbon receptor nuclear translocator~like 2), MOP9, CLIF or PASD9, is a 636 amino acid protein that localizes to the nucleus and contains one bHLH (basic helix~loop~helix) domain, one PAC (PAS~associated C~terminal) domain and two PAS (PER~ARNT~SIM) domains. Expressed at high levels in placenta and brain and at lower levels in liver, thymus, heart, lung and kidney, BMAL2 functions as a component of the circadian core oscillator, which includes a variety of proteins that work in tandem to activate the transcription of target genes. More specifically, BMAL2, when functioning as a component of the core oscillator, binds to the E~box element (3'~CACGTG~5') of target DNA, thus inducing transcription. Multiple isoforms of BMAL2 exist due to alternative splicing events.