Rabbit polyclonal antibody to LFR

Intelectin~1, also known as ITLN1, INTL, Omentin or LFR, is a 313 amino acid protein that contains one fibrinogen C~terminal domain and is either secreted or lipid~anchored to the cell membrane. Highly expressed in small intestine and adipose tissue and present at lower levels in testis, heart, pancreas, colon and skeletal muscle, Intelectin~1 exists as a disulfide~linked homotrimer that functions to enhance Insulin~stimulated glucose uptake and is also thought to participate in host defense against miccroorganisms. In addition to its roles in glucose regulation and immune system function, Intelectin~1 may also be involved in iron metabolism and obesity regulation in adults. Intelectin~2 shares 85% amino acid identity with Intelectin~1 and, like Intelectin~1, is a secreted protein that contains one fibrinogen C~terminal domain and is thought to play a role in the host defense system. While Intelectin~1 is present in a variety of tissues, Intelectin~2 exists only in the small intestine.