Rabbit polyclonal antibody to LFR

Intelectin~1, also known as ITLN1, INTL, Omentin or LFR, is a 313 amino acidprotein that contains one fibrinogen C~terminal domain and is either secretedor lipid~anchored to the cell membrane. Highly expressed in small intestineand adipose tissue and present at lower levels in testis, heart, pancreas, colonand skeletal muscle, Intelectin~1 exists as a disulfide~linked homotrimer thatfunctions to enhance Insulin~stimulated glucose uptake and is also thought toparticipate in host defense against miccroorganisms. In addition to its rolesin glucose regulation and immune system function, Intelectin~1 may also beinvolved in iron metabolism and obesity regulation in adults. Intelectin~2shares 85% amino acid identity with Intelectin~1 and, like Intelectin~1, is asecreted protein that contains one fibrinogen C~terminal domain and is thoughtto play a role in the host defense system. While Intelectin~1 is present in avariety of tissues, Intelectin~2 exists only in the small intestine.