Rabbit polyclonal antibody to NURR1

Nurr1 (Nur~related factor 1) and Nur77 (also designated NGFI~B) encodeorphan nuclear receptors which may comprise an additional subfamily withinthe nuclear receptor superfamily. The rat and human homologs of mouse Nurr1are designated RNR1 and NOT, respectively. Both Nurr1 and Nur77 are growthfactor inducible, immediate early response genes. Induction of both Nurr1 andNur77 is seen after membrane depolarization while only Nur77 induction isseen with NGF stimulation. JunD acts as a mediator for Nur77. An increase in Nurr77 expression is seen in activated T cells during G0 to G1 transition andthroughout the G1 phase. In addition to its function as an immediate earlygene, Nur77 may play a role in TCR~mediated apoptosis. Cyclosporin A, apotent immuno~suppressant, has been shown to inhibit the ability of Nur77to bind DNA. A dominant negative form of Nur77 can protect T cell hybridomas from activation~induced apoptosis. However, the absolute requirementof Nur77 for TCR~mediated apoptosis is still under debate.