Rabbit polyclonal antibody to PXR

Steroid hormones function as signaling molecules by diffusing into cells and interacting with specific intracellular receptors to regulate gene expression. This superfamily of receptors includes both steroid and nonsteroid receptors. Like many nonsteroid hormone receptors, PXR (pregnane X receptor) binds as a heterodimer with RXR to a DNA sequence typical of a nonsteroid hormone receptor; however, PXR is activated by several steroids, such as naturally occurring pregnanes and synthetic glucocorticoids and anti~ glucocorticoids. PXR exists as two alternatively spliced isoforms, PXR.1 and PXR.2. PXR is thought to define a novel steroid hormone signaling pathway that may account for some of the effects of synthetic glucocorticoids and antiglucocorticoids that are not mediated through the classical glucocorticoid receptor signaling pathway.